When they withdraw their heads into their shells rapidly it forces air out & produces a hiss. They do this when they're scared. He's not happy about being picked up. See if you can find a way to approach him and lift him without scaring him. Talking soothingly helps. Normal, yes. Good, no.
A lot of tortoises don't like being picked up. They don't like not feeling anything solid to grip onto. My russian squeaks sometimes too (he always wants food!!) and it is really cute!